TRATAMENTO SUBAGUDO DOS ÓLEOS ESSENCIAIS DE COPAÍBA E BREU BRANCO USANDO RESPOSTAS DE BIOMARCADORES INTEGRADOS NO SISTEMA REPRODUTIVO DE RATOS WISTAR EXPOSTOS AO ÁCIDO VALPRÓICO
DOI:
https://doi.org/10.18554/194cd652Keywords:
toxicologia, testículo, epidídimo, ácido valpróicoAbstract
O ácido valpróico é um ácido graxo de cadeia curta, utilizado como tratamento para epilepsia. O tratamento com ácido valpróico apresenta vários efeitos colaterais como subfertilidade masculina, causando alterações reversíveis na motilidade do espermatozoide, morfologia, contagem de espermatozoides e citoarquitetura dos testículos. Objetivou-se entender como o uso do ácido valpróico durante a gestação pode afetar a fertilidade da prole masculina, e se o uso de óleos essenciais de copaíba, breu branco ou a associação deles pode reverter os danos causados. as ratas do grupo controle negativo receberam água e as dos grupos experimentais receberam ácido valpróico (600 mg/kg), por via intraperitoneal, uma única vez. Os filhotes machos foram divididos em seis grupos: controles negativo e positivo; veículo; tratado com óleo de copaíba; com óleo breu branco e com óleo de copaíba associado ao breu branco. Os óleos do TERRA® foram administrados via gavagem, por 30 dias consecutivos. Como resultados observamos estresse oxidativo e nitrosativo testicular e epididimário, e uma alteração da atividade das enzimas antioxidantes. Alterações testiculares leves e áreas cribiforme epididimária. Conclui-se que a exposição ao ácido valpróico durante o período intrauterino casa danos oxidativos e alterações estruturais tanto testiculares como epididimário, porém o uso dos óleos essenciais nesta dose e tempo não foram suficientes para reverter esses danos mesmo alterando a atividade das enzimas antioxidantes.
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