Analysis of the frequency of the rs2858060 polymorphism in the gene encoding microRNA-221 in patients with Polycystic Ovary Syndrome.
DOI:
https://doi.org/10.18554/acbiobras.v8i2.8497Keywords:
Polycystic Ovary Sydrome, genetic polymorphism, microRNAAbstract
Polycystic Ovary Syndrome (PCOS) is an endocrine disorder of multifactorial etiology, involving both environmental and genetic factors, including polymorphisms in microRNA-encoding genes. This study aimed to investigate the frequency of the rs2858060 polymorphism in the gene encoding miR-221 in patients with PCOS and compare it with controls. To this end, genomic DNA was extracted from 81 patients with PCOS and 99 women without signs of the syndrome. The polymorphism was analyzed using the Real-Time PCR Allelic Discrimination technique, and data were analyzed using the Chi-Square test. The results showed no statistically significant difference in the frequency of the polymorphism (P = 0.96) between patients and controls. In conclusion, in the sample analyzed, there was no association between the rs2858060 polymorphism in the gene encoding miR-221 and PCOS.
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