Therapeutic associations on the management of chemo-induced oral mucositis in pediatric patients

Authors

  • Raphael Cavalcante Costa
  • Rebecca Rhuanny Tolentino Limeira
  • Laís Guedes Alcoforado de Carvalho
  • Paulo Rogério Ferreti Bonan
  • Ana Maria Gondim Valença
  • Isabella Lima Arrais Ribeiro

DOI:

https://doi.org/10.18554/refacs.v6i2.2823

Keywords:

Oncology service hospital, Lasers, Mucositis

Abstract

The objective of this study was to present 10 cases of severe oral mucositis treated with an oral mouthwash solution associated with low potency laser therapy in pediatric oncology patients. The evaluated patients with oral mucositis had acute lymphoblastic leukemia, Osteosarcoma and Wilms’s tumor. The lesions presented in the following anatomical sites: vermilion of the lip, labial mucosa and tongue. The mean time for lesion regression was 6.8 ± 3.9 days. The treatment protocol consisted of an oral mouthwash solution (0.9% saline, nystatin, dexamethasone, diphenhydramine, morphine, 2% lidocaine, and vitamin B complex) and photodynamic therapy with low power laser (ECCO Fibers and Devices, n/s -040401; model -BM0004A), calibrated for a wavelength of 670 nm, power of 40mW and energy density of 4 J/cm2. All the patients had remission of oral mucositis lesions within 14 days after the initiation of the therapeutic intervention.  It was concluded that the protocol used with the use of low-power laser therapy combined with mouthwash solution was effective in the treatment of oral mucositis in pediatric patients undergoing antineoplastic treatment.

Author Biographies

Raphael Cavalcante Costa

Cirurgião-Dentista. Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil. ORCID: 0000-0002-1333-5227                                                                                                     E-mail: raphaelcavalcante_@hotmail.com.

Rebecca Rhuanny Tolentino Limeira

Fonoaudióloga. Mestranda em Ciências Odontológicas na UFPB. João Pessoa, PB, Brasil. ORCID: 0000-0001-7264-7426. E-mail: rebecca.rhuanny@hotmail.com.

Laís Guedes Alcoforado de Carvalho

Cirurgiã-Dentista. Mestranda em Ciências Odontológicas na UFPB, João Pessoa, PB, Brasil. ORCID: 0000-0003-2615-2582. E-mail: laisgac@gmail.com.

Paulo Rogério Ferreti Bonan

Cirurgião-Dentista. Doutor em Estomatopatologia. Professor da UFPB, João Pessoa, PB, Brasil. ORCID: 0000-0002-4449-4343. E-mail: pbonan@yahoo.com.

Ana Maria Gondim Valença

Cirurgiã-Dentista. Professora Titular do Departamento de Clínica e Odontologia Social na UFPB, João Pessoa, PB, Brasil.   ORCID: 0000-0001-8460-3981. E-mail: anamvalenca@gmail.com

Isabella Lima Arrais Ribeiro

Cirurgiã-Dentista.  Doutora em Modelos de Decisão e Saúde. Pós Doutora em Epidemiologia, João Pessoa, PB, Brasil. ORCID: 000-001-6538-6811. E-mail: isabella_arrais@yahoo.com

References

Grabois MF, Oliveira EX, Carvalho MS. Access to pediatric cancer care in Brazil: mapping origin-destination flows. Rev Saúde Pública. 2013; 47(2):368-78.

Hespanhol FL, Tinoco EMB, Teixeira HGC, Falabella MEV, Assis NMSP. Manifestações bucais em pacientes submetidos à quimioterapia. Ciênc Saúde Coletiva. 2010; 15(Supl. 1):1085-94.

Velten DB, Zandonade E, Miotto MHMB. Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy. BMC Oral Health. 2017; 17(1):49.

Campos MIDC, Campos CN, Aarestrup FM, Aarestrup BJV. Oral mucositis in cancer treatment: natural history, prevention and treatment. Mol Clin Oncol. 2014; 2(3):337-40.

Lima AG, Villar RC, Castro G, Antequera R, Gil E, Rosalmeida MC, et al. Oral mucositis prevention by low-level laser therapy in head-and-neck cancer patients undergoing concurrent chemoradiotherapy: a phase III randomized study. Int J Radiat Oncol Biol Phys. 2012; 82(1):270-5.

Cheng KK-F, Leung S, Liang RH, Tai JW, Yeung RM, Thompson DR. Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life. Support care cancer. 2010; 18(11):1477-85.

Rodrigues GH, Jaguar GC, Alves FA, Guollo A, Camandoni VO, Damascena AS, et al. Variability of high-dose melphalan exposure on oral mucositis in patients undergoing prophylactic low-level laser therapy. Lasers Med Sci. 2017; 32(5):1089-95.

Carneiro-Neto C, Moura LB, Menezes JDS, et al. Estadiamento TNM para o tratamento de câncer bucal. Rev Odontol (ATO). 2016; 16(3):100-8.

Cheng KK, Chang AM, Yuen M. Prevention of oral mucositis in paediatric patients treated with chemotherapy: a randomised crossover trial comparing two protocols of oral care. Eur J Cancer. 2004; 40(8):1208-16.

Lopes IA, Nogueira DN, Lopes IA. Manifestações orais decorrentes da quimioterapia em crianças de um centro de tratamento oncológico. Pesqui Bras Odontopediatria Clin Integr. 2012; 12(1):113-9.

Sung L, Yanofsky R, Klaassen RJ, Dix D, Pritchard S, Winick N, et al. Quality of life during active treatment for pediatric acute lymphoblastic leukemia. Int J Cancer. 2011; 128(5):1213-20.

Mendonça MA, Araújo MD, Levy CE, Morari J, Silva RA, Yunes JA, et al. Oral mucositis in pediatric acute lymphoblastic leukemia patients: evaluation of microbiological and hematological factors. Pediatr Hematol Oncol. 2015; 32(5):322-30.

Ribeiro ILA, Valença AMG, Bonan PRF. Treatment of severe oral mucositis in a pediatric patient undergoing chemotherapy. Rev Gaúcha Odontol. 2015; 63(4):467-71.

Júnior OR, Borba AM, Júnior JG. Prevenção e tratamento da mucosite bucal: o papel fundamental do cirurgião-dentista-revisão. Arch Oral Res. 2010; 6(1):57-62.

Lanzós I, Herrera D, Santos S, O’Connor A, Peña C, Lanzós E, et al. Mucositis in irradiated cancer patients: effects of an antiseptic mouthrinse. Med Oral Patol Oral Cir Bucal. 2010; 15(5):e732-8.

Peres P, Queiroz A, Moreira M, Faquim J, Ferrari M. Pediatric dentistry applied to childhood cancer-clinical manifestations and protocol service. J Manage Prim Health Care. 2013; 4(3):191-9.

Liang G, Du W, Ke Q, Huang B, Yang J. The effects of recombinant human granulocyte colony-stimulating factor mouthwash on radiotherapy-induced oral mucositis in locally advanced nasopharyngeal carcinoma patients. Adv. Clin. Exp. Med. 2017; 26(3):409.

Molina Prats P, Gómez Garcia F, Martinez Diaz F, Amaral Mendes R, Lopez‐Jornet P. The therapeutic effects of apigenin and dexamethasone on 5‐fluorouracil‐induced oral mucositis–a pilot study using a Syrian hamster model. J Oral Pathol Med. 2017; 46(2):142-7.

Onseng K, Johns NP, Khuayjarernpanishk T, Subongkot S, Priprem A, Hurst C, et al. Beneficial effects of adjuvant melatonin in minimizing oral mucositis complications in head and neck cancer patients receiving concurrent chemoradiation. J Altern Complement Med. 2017; 23(12):957-63.

Wong PC, Dodd MJ, Miaskowski C, Paul SM, Bank KA, Shiba GH, et al. Mucositis pain induced by radiation therapy: prevalence, severity, and use of self-care behaviors. J Pain Symptom Manage. 2006; 32(1):27-37.

Madden Kirk L, Brown SD, Luu Y, Ogle A, Huffman J, Lewis PO. Beyond-use dating of lidocaine alone and in two" magic mouthwash" preparations. Am J Health System Pharm. 2017; 74(9):e202-210.

Barasch A, Elad S, Altman A, Damato K, Epstein J. Antimicrobials, mucosal coating agents, anesthetics, analgesics, and nutritional supplements for alimentary tract mucositis. Support Care Cancer. 2006; 14(6):528-32.

Bonan P, Lopes M, Alves F, Almeida O. Aspectos clínicos, biológicos, histopatológicos e tratamentos propostos para a mucosite oral induzida por radioterapia: revisão da literatura. Rev Bras Cancerol. 2005; 51(3):235-42.

Cardoso MdFA, Novikoff S, Tresso A, Segreto RA, Cervantes O. Prevenção e controle das seqüelas bucais em pacientes irradiados por tumores de cabeça e pescoço. Radiol bras. 2005; 38(2):107-15.

Carneiro TV, Ribeiro ILA, Alves CV, Bonan PRF, Neto EdAL, Valença AMG. Factors associated with health-related quality of life among children with cancer from the standpoint of patients and caregivers. J Public Health. 2017; 25(4): 371–7.

Figueiredo ALP, Lins L, Cattony AC, Falcão AFP. Laserterapia no controle da mucosite oral: um estudo de metanálise. Rev Assoc Méd Bras. 2013; 59(5):467-74.

Oberoi S, Zamperlini–Netto G, Beyene J, Treister NS, Sung L. Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. PLoS one. 2014; 9(9):e107418.

Published

2018-04-05

How to Cite

Costa, R. C., Limeira, R. R. T., Carvalho, L. G. A. de, Bonan, P. R. F., Valença, A. M. G., & Ribeiro, I. L. A. (2018). Therapeutic associations on the management of chemo-induced oral mucositis in pediatric patients. JOURNAL FAMILY, CYCLES OF LIFE AND HEALTH IN SOCIAL CONTEXT, 6(2), 256–263. https://doi.org/10.18554/refacs.v6i2.2823