Correlação entre anti-desmogleína e lesões mucocutâneas em pacientes com pênfigo vulgar ou foliáceo

Mara Ilka Holanda Medeiros Batista, Marcilia Ribeiro Paulino, Carlus Alberto Oliveira dos Santos, Samantha Camargo de Andrade, Camila Andrade Lima, Luiz Alcino Gueiros, Jair Carneiro Leão, Alessandra Albuquerque Tavares Carvalho

Resumo


Essa é uma pesquisa não-probabilística e transversal. O objetivo deste estudo foi correlacionar a imunodetecção de anti-desmogleína 1 e 3 no soro de pacientes com pênfigo vulgar (PV) ou pênfigo foliáceo (PF) com a presença de lesões mucocutâneas. Pacientes foram selecionados por uma amostra de conveniência baseada na demanda espontânea nas unidades de Dermatologia e Medicina Oral da Universidade Federal do Pernambuco, Recife, Brasil, de fevereiro a novembro de 2012. Vinte e seis indivíduos (18 mulheres, 69,2% e 8 homens, 30,8%) foram avaliados, 20 diagnosticados com PV (73,1%) e 6 com PF (26,9%). O teste ELISA foi usado para determinar a presença de anti-desmogleína 1 e 3 no soro. A presença de anti-desmogleína 1 foi associada a lesões na pele  (p=0,038) e a de anti-desmogleína 3 a lesões mucosais (p = 0,041). Nesse estudo, o ELISA se mostrou altamente sensível ao DSG1 e ao DSG3, de acordo com o fenótipo da doença. 


Palavras-chave


Pênfigo; Ensaio de Imunoadsorção Enzimática; Dermatopatias Vesiculobolhosas; Doenças Autoimunes

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DOI: https://doi.org/10.18554/refacs.v7i1.2918

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