Correlation between anti-desmoglein and mucocutaneous lesions in patients with pemphigus vulgaris or foliaceus

Authors

DOI:

https://doi.org/10.18554/refacs.v7i1.2918

Keywords:

Pemphigus, Enzyme-linked Immunosorbent Assay, Vesiculobullous, Autoimmune Diseases

Abstract

This research was a non-probability cross-sectional. The aim of the present study was to correlate the immunodetection of anti-desmoglein 1 and 3 in the serum of pemphigus vulgaris (PV) or pemphigus foliaceus (PF) patients with the presence of mucocutaneous lesions. Patients were selected through convenience sampling based on spontaneous demand at the Dermatology and Oral Medicine units of the Universidade Federal de Pernambuco, Recife, Brazil at February until November of 2012. Twenty-six individuals (18 women, 69.2% and 8 men, 30.8%) were evaluated, 20 diagnosed with PV (73.1%) and 6 with PF (26.9%). ELISA test was used to determine the presence of anti-desmoglein 1 and 3 in the serum. Anti-desmoglein 1 positivity was associated to skin lesions (p=0.038) and anti-desmoglein 3 to mucosal lesions (p = 0.041). On this study, ELISA was shown to be highly sensitive for DSG1 and DSG3 in accordance with the phenotype of the disease. 

Author Biographies

Mara Ilka Holanda Medeiros Batista, Centro Universitário de João Pessoa - UNIPÊ

Cirurgiã-dentista. Especialista em Odontologia. Mestre em Perícias Forenses. Doutoranda em Odontologia. Curso de Aperfeiçoamento em Ortodontia e Aperfeiçoamento em Estética e Cosmética em Odontologia. Professora assistente do curso de Odontologia do UNIPÊ.

Marcilia Ribeiro Paulino, Faculdade Leão Sampaio

Graduação em Odontologia. Mestre área de Concentração Odontologia. Doutoranda do Programa de Pós-Graduação em Odontologia. Professora Substituta de Prótese.

Carlus Alberto Oliveira dos Santos, Centro Universitário de João Pessoa - UNIPÊ

Bacharel em Odontologia. Monitoria nas disciplinas de Materiais Dentários, Endodontia e Microbiologia.

Samantha Camargo de Andrade, Universidade Federal de Pernambuco

Graduação em Odontologia. Mestre em Odontologia. Professora substituta da disciplina de Periodontia pelo Departamento de Clínica e Odontologia Preventiva Doutoranda em Odontologia.

Camila Andrade Lima, Universidade Federal de Pernambuco

Graduação em Odontologia. Especialização em Implantodontia. Aperfeiçoamento em Cirurgia.    Mestrado em Odontologia.

Luiz Alcino Gueiros, Universidade Federal de Pernambuco

Graduação em Odontologia. Especialista em Estomatologia. Doutor em Estomatopatologia. Pós-doutorado no Programa de Pós-graduação em Odontologia. Professor Adjunto III da Disciplina de Estomatologia, Departamento de Clínica e Odontologia Preventiva.

Jair Carneiro Leão, Universidade Federal de Pernambuco

Graduação em Odontologia. Mestrado, Doutorado e por duas vezes Pós-Doutorado no Eastman Dental Institute da Universidade de Londres em 2004 e 2012. Professor Titular do Curso de Odontologia da Universidade Federal de Pernambuco. Em nível internacional é Honorary Professor da University College London e Diplomat da European Association of Oral Medicine.

Alessandra Albuquerque Tavares Carvalho, Universidade Federal de Pernambuco

Graduação em Odontologia. Doutorado em Odontologia. Membro do colegiado da Pós-Graduação em Odontologia e do Departamento de Clinica e Odontologia Preventiva. Coordenadora do Programa de Pós-Graduação em Odontologia da Universidade Federal de Pernambuco. Professor Pós-Graduação em Odontologia.

References

De D, Khullar G, Handa S, Joshi N, Saikia B, Minz RW. Correlation between salivary and serum anti-desmoglein 1 and 3 antibody titres using ELISA and between anti-desmoglein levels and disease severity in pemphigus vulgaris. Clin Exp Dermatol. 2017; 42(6):648-50.

Feller L. Immunopathogenic oral diseases: an overview focusing on pemphigus vulgaris and mucous membrane pemphigoid. Oral Health Prev Dent. 2017; 15(2):177–82.

Ruocco V, Ruocco E, Lo Schiavo A, Brunetti G, Guerrera LP, Wolf R. Pemphigus: etiology, pathogenesis, and inducing or triggering factors: facts and controversies. Clin Dermatol. 2013; 31(4):374–81.

Santosh ABR, Addam VRR. Oral mucosal lesion in pa/ents with pemphigus and pemphigoid skin diseases: across sec/onal study from southern India. Dentistry 3000. 2017; 5(1):1-7.

Perks AC. A case of concomitant pemphigus foliaceus and oral pemphigus vulgaris. Head Neck Pathol. 2018; 1(1):1-6.

Tamgadge S, Tamgadge A, Bhatt DM, Bhalerao S, Pereira T. Pemphigus vulgaris. Contemp Clin Dent. 2011; 2(2):134-7.

Neumann-Jensen B, Worsaae N, Dabelsteen E, Ullman S. Pemphigus vulgaris and pemphigus foliaceus coexisting with lichen planus. Br J Dermatol. 1980; 102(5):585–90.

Sharma M. Oral pemphigus vulgaris. J Kathmandu Med Coll. 2015; 4(3):100-3.

Patsatsi A, Kyriakou A, Giannakou A, Pavlitous-Tsiontsi A, Lambropoulos A, Dimitrios Sotiriadis D. Clinical significance of anti-desmoglein -1 and -3 circulating autoantibodies in pemphigus patients measured by Area Index and Intensity Score. Acta Derm Venereol. 2014; 94(2):203-6.

Reeves GMB, Lloyd M, Rajlawat BP, Barker GL, Field EA, Kaye SB. Ocular and oral grading of mucous membrane pemphigoid. Graefes Arch Clin Exp Ophthalmol. 2012; 250(4):611-8.

Ni Riordain R, Shirlaw P, Alajbeg I. World Workshop on Oral Medicine VI: patient reported outcome measures and oral mucosal disease: current status and future direction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120(2):161-71.e20.

Di Zenzo G, Carrozzo M, Chan LS. Urban legend series: mucous membrane pemphigoid. Oral Dis. 2014; 20(1):35–54.

Izumi T, Seishima M, Satoh S, Ito A, Kamija H, Kitajima Y. Pemphigus with features of both vulgaris and foliaceus variants associated with antibodies to 160 and 130 kDa antigens. Br J Dermatol. 1998; 139(4):688-92.

Cunha PR, Bystryn JC, Medeiros EPL, Oliveir,a JR. Sensitivity of indirect immunofluorescence and ELISA in detecting intercellular antibodies in endemic pemphigus foliaceus. Int J Dermatol. 2006; 45(8):914-8.

Oiso N, Yamashita C, Yoshioka K, Amagai M, Komai A, Nagata A. IgG/IgA pemphigus with IgG and IgA antidesmoglein 1 antibodies detected by enzyme-linked immunosorbent assay. Br J Dermatol. 2002; 147(5):1012-7.

Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Shimizu A. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus expressed recombinant desmogleins. J Immunol. 1997; 159(4):2010-7.

Mortazavi H, Khatami A, Seyedin Z, Farahani IV, Daneshpazhoohi M. Salivary desmogleína enzyme-linked immunosorbent assay for diagnosis of pemphigus vulgaris: a noninvasive alternative test to serum assessment. Biomed Res. Int. [Internet]. 2015 [citado em 14 out 2017]; ID 698310:1-7. Disponível em: https://www.hindawi.com/journals/bmri/2015/698310/

Sami N, Bhol C, Ahmed AR. Diagnostic features of pemphigus vulgaris in patients with pemphigus foliaceus: detection of both autoantibodies, long-term follow-up and treatment responses. Clin Exp Immunol. 2001; 125(3):492-8.

Shamim T, Varghese VI, Shameena PM, Sudha S. Pemphigus vulgaris in oral cavity: clinical analysis of 71 cases. Med Oral Patol Oral Cir Bucal. 2008; 13(10):E622-6.

Amagai M. Desmoglein as a target in autoimmunity and infection. J Am Acad Dermatol. 2006; 48(2):244-52.

Kouskoukis CE, Ackerman AB. Vacuoles in the upper part of the epidermis as a clue to eventuation of superficial pemphigus and bullous impetigo. Am J Dermatopathol. 1984; 6(2):183-6.

Ito T, Moriuchi R, Kikuchi K, Shimizu S. Rapid transition from pemphigus vulgaris to pemphigus foliaceus. J Eur Acad Dermatol Venereol. 2016; 30(3):455-7.

McMillan R, Taylor J, Shephard M, Ahmed R, Carrozzo M, Setterfield J, et al. World Workshop on Oral Medicine VI: a systematic review of the treatment of mucocutaneous pemphigus vulgaris. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120(2):132-42.

Teixeira TA, Fiori FCBC, Silvestre MC, Borges CB, Maciel VG, Costa MB. Refractory endemic pemphigus foliaceous in adolescence successfully treated with intravenous immunoglobulin. An Bras Dermatol. 2011; 86(4Suppl 1):S133-6.

Downloads

Published

2019-01-29

How to Cite

Batista, M. I. H. M., Paulino, M. R., Oliveira dos Santos, C. A., Andrade, S. C. de, Lima, C. A., Gueiros, L. A., Leão, J. C., & Carvalho, A. A. T. (2019). Correlation between anti-desmoglein and mucocutaneous lesions in patients with pemphigus vulgaris or foliaceus. JOURNAL FAMILY, CYCLES OF LIFE AND HEALTH IN SOCIAL CONTEXT, 7(1), 16–22. https://doi.org/10.18554/refacs.v7i1.2918

Issue

Vol. 7 No. 1 (2019): Janeiro a Março

Section

Original Articles

License

Each of the authors of the manuscript must complete and sign a copy of Statement of Responsibility and Copyright Transfer Agreement, which must be attached, by the submitting author, in step 4 of the submission process in the journal system (Click on the "Browse" option, select the file that should be inserted in pdf format, click on the "Download" button, in the "Title" field type: Declaration of responsibilities, then click the "Save and Continue" button and proceed with the submission process.

Note: Including scanned signature will not be accepted. Each author of the manuscript must complete a declaration individually.

 

 

Licença Creative Commons
REFACS de Universidade Federal do Triângulo Mineiro está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional.
Baseado no trabalho disponível em www.uftm.edu.br.
Podem estar disponíveis autorizações adicionais às concedidas no âmbito desta licença em http://www.uftm.edu.br/refacs.