EVALUATION OF THE TOXICITY OF COPAIBA OLEORESIN (Copaifera reticulata Ducke) IN NATURA AND OINTMENT IN THE SKIN OF WISTARS RATS
DOI:
https://doi.org/10.18554/0c01w621Keywords:
Medicinal Plants, Therapeutic Uses, Skin Irritancy TestsAbstract
The use of medicinal plants without caution and monitoring can cause reactions of intrinsic and extrinsic causes. Research aimed at the safe use of medicinal plants is still scarce, therefore, the objective of this work is to evaluate the dermal toxicity of oleoresin from copaiba, one of the main natural resources used for various therapeutic purposes by the traditional community. To verify the dermal toxicity of C. reticulata Ducke ointment, the recommendations of the Organization for Economic Cooperation and Development (OECD) 404/2015 protocol were used, both in natura form and as a 10% ointment, in a single application and during 14 days on the back of wistar rats. After the test, it was possible to verify that the use of C. reticulata Ducke oleoresin in natura can cause irritating/corrosive effects, differently from its ointment formulation.
References
1. Santana RS, Bianchini-Pontuschka R, Hurtado FB, Oliveira CA, Melo LPR, Santos GJ. Uso medicinal do óleo de copaiba (Copaifera sp.) por pessoas de melhor idade no Município de Presidente Médici, Rondônia, Brasil. Acta Agronomica, v.63, n.4, 2014. https://repositorio.unal.edu.co/handle/unal/48932.
2. Azani N, Babineau M, Bailey CD, Banks HI. A new subfamily classification of the Leguminosae based on a taxonomically comprehensive phylogheny. Taxon. v. 66, n. 1, p. 44-77, 2017. https://doi.org/10.12705/661.3.
3. Barquete CC, Oliveira RS, Neves EC, Pelizzari C, Santos JF, Souza RG, Caleffo T, Viott AM, Laskoski LM, Souza AF. Copaiba oil-resin (Copaifera langsdorfii Desf.: Caesalpiniaceae) associated with laser therapy for skin wound treatment in Wistar rats, Acta Veterinaria Brasilica December, 15, 304-309, 2021. http://dx.doi.org/10.21708/avb.2021.15.4.10017.
4. Lima CS, Medeiros BJ, Favacho HA, Santos KC, Oliveira BR, Taglialegna JC, Costa EV, Campos KJ, Carvalho JC. Pré-clinical validation of a vaginal cream containing copaiba oil (reproductive toxicology study). Phytomedicine. 18, 1013–1023, 2011. doi: 10.1016/j.phymed.2011.05.004.
5. Ferreira AD, Rocha CP, Vieira LM, Dusse LMS, Junqueira DRG, Carvalho MG. Alterações hematológicas induzidas por medicamentos convencionais e alternativos. Rev. Bras. Farm. v. 94, n. 2, p. 94-101, 2013. https://www.inesul.edu.br/atividades/arquivos/Material1_1462485211.pdf.
6. Brasil. Agência Nacional de Vigilância Sanitária. Formulário de Fitoterápicos da Farmacopéia Brasileira / Agência Nacional de Vigilância Sanitária. Brasília: Anvisa, 2011. https://www.gov.br/anvisa/pt-br/assuntos/farmacopeia/formulario-fitoterapico/1a-edicao-revogada.
7. OECD (Organization for economic co-operation and development). Guideline for testing of chemicals: 404 - acute dermal irritation/corrosion, 2015. https://doi.org/10.1787/9789264242678-en.
8. Lima, HS. Potencial anti-inflamatório da oleorresina de Copaifera paupera (Herzog) Dwyer – Leguminosae. Dissertação (Mestrado em Biociências) – Universidade Federal do Oeste do Pará, 2015.
9. Morini AC, Marinho DF, Araujo JAS. Avaliação da ação terapêutica de Copaifera duckei Dwyer em uso tópico por fonoforese. Archives of veterinary science, v.21, p. 59-63, 2016.
10. Estevão LRM, Medeiros JP, Scognamillo-Szabó MVR, Baratella-Evêncio L, Guimarães EC, Câmara CAG da, Evêncio-Neto J. Neoangiogênese de retalhos cutâneos em ratos tratados com óleo de copaíba. Pesq. agropec. bras., Brasília, v. 44, n. 4, p. 406-412, abr. 2009. https://doi.org/10.1590/S0100-204X2009000400011.
11. Lima CS, Silva UDA, Goes LDM, Hyacienth MS, Carvalho HO, Fernandes CP, Castro NA, Carvalho JCT. Non-clinical toxicity study of the oil-resin and vaginal cream of Copaiba (Copaifera duckei, Dwyer). Cogent Biology, v.13, p. 1-33, 2017. https://doi.org/10.1080/23312025.2017.1394510.
12. Carvalho, JCT. Topical antiinflammatory and analgesic activities of Copaifera duckei dwyer. Phytother. Rev. v. 19, p. 946 – 950, 2005. ttps://doi.org/10.1002/ptr.1762.
13. Brito MVH, Figueiredo RC, Tavares MLC, Silveira TS, Cantanhêde G. Efeito dos óleos de andiroba e copaíba na miosite induzida em ratos / Andiroba and copaiba oils effect in induced miositis in rats. Rev. para. med ; 20(2): 17-24, abr.-jun. 2006.
14. Gonçalves ES, Silva JR, Gomes CL, Nery MBL. Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats. Revista Brasileira de Farmacognosia, v. 24, n. 3, p. 355-362, 2014. https://doi.org/10.1016/j.bjp.2014.07.014.
15. Giesbrecht PCP. Efeito da pomada de óleo de copaíba em queimadura cutânea em ratos. Dissertação (Mestrado em Ciência Animal) – Centro Universitário Vila Velha, 2011.
16. Costa AS, Lameira OA. Phytochemical study of oleoresin extracted from Copaifera reticulata Ducke (Leguminosae-Caesalpiniodade) in a sustainable management area. Research, Society and Decelopment, v.10, n.16, 2021. https://doi.org/10.33448/rsd-v10i16.22305.
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