ATUALIZAÇÕES NO DESENVOLVIMENTO DA BIOIMPRESSÃO 3D A PARTIR DE ESTRUTURAS DESCELULARIZADAS: UMA REVISÃO NARRATIVA
DOI:
https://doi.org/10.18554/gnzx6m36Keywords:
Regenerative Medicine, 3D Bioprinting, Tissue Engineering, DecellularizationAbstract
A medicina regenerativa avançou significativamente nas últimas duas décadas, com a engenharia de tecidos desempenhando um papel fundamental na expansão das possibilidades de aplicação e na resolução de desafios médicos. A descelularização de tecidos e órgãos acelerou os esforços em bioengenharia, aprimorando as estratégias de reparo para diversos tipos de lesões. A adaptabilidade dessa técnica permitiu sua aplicação em múltiplos tipos de tecidos, sendo que alguns métodos demonstraram maior eficiência e potencial para integração clínica. Este estudo tem como objetivo documentar os ajustes nas técnicas de descelularização, principais avanços e aplicações no reparo de tecidos e órgãos. Utilizando uma abordagem retrospectiva e descritiva, esta revisão narrativa aborda tanto os aspectos gerais quanto específicos da descelularização. Os principais tópicos incluem os princípios básicos, as técnicas primárias, os avanços, as aplicações e as perspectivas futuras dos métodos de descelularização. Espera-se que esta revisão solidifique as principais evidências que sustentam as estratégias de reparo de órgãos e tecidos por meio da descelularização e forneça insights ou gere perguntas para novas pesquisas, contribuindo para a melhoria da qualidade de vida através de estudos primários mais direcionados.
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