A 10-year survey of dermatomycoses in Uberaba, southeast Brazil

Authors

  • Ana Gabriela Magalhães Gomes de Oliveira
  • Diego Batista Carneiro de Oliveira UFTM
  • Guilherme Ferreira de Oliveira

DOI:

https://doi.org/10.18554/acbiobras.v7i2.7965

Keywords:

dermatomicoses, dermatófitos, epidemiologia, fungos filamentosos não dermatófitos, candidíase superficial.

Abstract

As infecções fúngicas superficiais, conhecidas como dermatomicoses, estão entre as principais patologias dermatológicas e afetam aproximadamente 25% da população mundial. Conhecer a epidemiologia e promover o diagnóstico dessas micoses é essencial para a administração adequada do tratamento. Foram coletadas 2.325 amostras de pele, unhas e cabelos de todos os pacientes atendidos em um laboratório clínico privado na cidade de Uberaba - Minas Gerais - com suspeita clínica de dermatomicose entre agosto de 2012 e julho de 2022 e identificadas por meio de metodologia clássica e pelo sistema VITEK®2 YST ID. Das amostras coletadas, 1.327 (57,10%) foram positivas para fungos, sendo a maioria de amostras de unhas (61,64%), seguidas por amostras de pele dos pés (14,92%) e do corpo (11,75%). Destas, a maioria era de pacientes entre 31 e 40 anos (18,23%), e a maioria das amostras de couro cabeludo foi obtida de pacientes com até 10 anos de idade (91,66%). Os fungos mais frequentes foram dermatófitos (48,61%), seguidos por leveduras (28,79%) e fungos filamentosos não dermatófitos (FNDF) (22,61%), e as espécies mais comuns foram Trichophyton rubrum (41,22%), Candida parapsilosis (13,34%), Candida albicans (7,69%) e Aspergillus sp. (6,63%). Os dados aqui encontrados corroboram os resultados da maioria dos estudos encontrados na literatura e ressaltam a importância de se conhecer a prevalência dos agentes etiológicos dessas micoses para que o tratamento correto possa ser administrado e, consequentemente, casos de prescrição empírica, recidiva e resistência antifúngica possam ser evitados.

References

Gunaydin SD, Arikan-Akdagli S, Akova M. Fungal infections of the skin and soft tissue. Curr Opin Infect Dis. 2020; 33(2):130-136. https://doi.org/10.1097/QCO.0000000000000630.

Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycoses. 2008; 51(Suppl4):2-15. https://doi.org/10.1111/j.1439-0507.2008.01606.x.

Zhan P, Liu W. The changing face of dermatophytic infections worldwide. Mycopathologia. 2017; 182(1-2):77-86. https://doi.org/10.1007/s11046-016-0082-8.

Heidrich D, Stopiglia CDO, Magagnin CM, Daboit TC, Vettorato G, Amaro TG, Scroferneker ML. Sixteen years of dermatomycosis caused by Candida spp. in the metropolitan area of Porto Alegre, southern Brazil. Rev Inst Med Trop Sao Paulo. 2016; 58:14. https://doi.org/10.1590/S1678-9946201658014.

Narang T, Bhattacharjee R, Singh S, Jha K, Kavita, Mahajan R, Dogra S. Quality of life and psychological morbidity in patients with superficial cutaneous dermatophytosis. Mycoses. 2019; 62(8):680-685. https://doi.org/10.1111/myc.12930.

Patel VM, Schwartz RA, Lambert WC. Topical antiviral and antifungal medications in pregnancy: a review of safety profifiles. J Eur Acad Dermatol. 2017; 31:1440-1446. https://doi.org/10.1111/jdv.14297.

Benedict K, Gold JAW, Wu K, Lipner SR. High Frequency of Self-Diagnosis and Self-Treatment in a Nationally Representative Survey about Superficial Fungal Infections in Adults-United States, 2022. J Fungi (Basel). 2022; 9(1):19. https://doi.org/10.3390/jof9010019.

Hay RJ. The Spread of Resistant Tinea and the ingredients of a perfect storm dermatology. Dermatology. 2022; 238(1):80-81. https://doi.org/10.1159/000515291.

Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A. The global problem of antifungal resistance: prevalence, mechanisms, and management. Lancet Infect Dis. 2017; 17:383-392. https://doi.org/10.1016/S1473-3099(17)30316-X.

Gupta AK, Venkataraman M. Antifungal resistance in superficial mycoses. J Dermatolog Treat. 2022; 33(4):1888-1895. https://doi.org/10.1080/09546634.2021.1942421.

ANVISA, Agência Nacional de Vigilância Sanitária - Microbiologia Clínica para o Controle de Infecção Relacionada à Assistência à Saúde. Módulo 8: Detecção e identificação de fungos de importância médica; 2013.

Köhler JR, Hube B, Puccia R, Casadevall A, Perfect JR. Fungi that infect humans. Microbiol Spectr. 2017; 5(3). https://doi.org/10.1128/microbiolspec.FUNK-0014-2016.

Charles AJ. Superficial cutaneous fungal infections in tropical countries. Dermatol Ther. 2009; 22(6):550-9. https://doi.org/10.1111/j.1529-8019.2009.01276.x.

Vallabhaneni S, Mody RK, Walker T, Chiller T. The Global Burden of Fungal Diseases. Infect Dis Clin North Am. 2016; 30(1):1-11. https://doi.org/10.1016/j.idc.2015.10.004.

Nweze EI, Eke IE. Dermatophytes and dermatophytosis in the eastern and southern parts of Africa. Med Mycol. 2018; 56(1):13-28. https://doi.org/10.1093/mmy/myx025.

Silva LB, Oliveira DBC, Silva BV, Souza RA, Silva PR, Ferreira-Paim K, Andrade-Silva LE, Silva-Vergara ML, Andrade AA. Identification and antifungal susceptibility of fungi isolated from dermatomycoses. J Eur Acad Dermatol Venereol. 2014; 28(5):633-640. https://doi.org/10.1111/jdv.12151.

Kovitwanichkanont T, Chong AH. Superficial fungal infections. Aust J Gen Pract. 2019; 48(10):706-711. https://doi.org/10.31128/AJGP-05-19-4930.

Pereira FO, Gomes SM, Silva SL, Teixeira APC, Lima IO. The prevalence of dermatophytoses in Brazil: a systematic review. J Med Microbiol. 2021; 70(3). https://doi.org/10.1099/jmm.0.001321.

Nowicka D, Nawrot U. Tinea pedis – An embarrassing problem for health and beauty - A narrative review. Mycoses. 2021; 64(10):1140-1150. https://doi.org/10.1111/myc.13340.

Gupta AK, Stec N, Summerbell RC, Shear NH, Piguet V, Tosti A, Piraccini BM. Onychomycosis: a review. J Eur Acad Dermatol Venereol. 2020; 34(9):1972-1990. https://doi.org/10.1111/jdv.16394.

Gupta AK, Venkataraman M, Shear NH, Piguet V. Onychomycosis in children - review on treatment and management strategies. J Dermatolog Treat. 2022; 33(3):1213-1224. https://doi.org/10.1080/09546634.2020.1810607.

Gupta AK, Versteeg SG, Shear NH. Onychomycosis in the 21st century: an update on diagnosis, epidemiology and treatment. J Cutan Med Surg. 2017; 21(6):525-539. https://doi.org/10.1177/1203475417716362.

Chen XQ, Yu J. Global Demographic Characteristics and Pathogen Spectrum of Tinea Capitis. Mycopathologia. 2023; 188(5):433-447. https://doi.org/10.1007/s11046-023-00710-8.

Leung AKC, Hon KL, Leong KF, Barankin B, Lam JM. Tinea capitis: an updated review. Recent Pat Inflamm Allergy Drug Discov. 2020; 14(1):58-68. https://doi.org/10.2174/1872213X14666200106145624.

Menu E, Filori Q, Dufour JC, Ranque S, L'Ollivier C. A Repertoire of Clinical Non-Dermatophytes Moulds. J Fungi (Basel). 2023; 9(4):433. https://doi.org/10.3390/jof9040433.

Moreno G, Arenas R. Other fungi causing onychomycosis. Clin Dermatol. 2010; 28(2):160-163. https://doi.org/10.1016/j.clindermatol.2009.12.009.

Gupta AK, Drummond-Main C, Cooper EA, Brintnell W, Piraccini BM, Tosti A. Systematic review of nondermatophyte mold onychomycosis: diagnosis, clinical types, epidemiology, and treatment. J Am Acad Dermatol. 2012; 66(3):494-502. https://doi.org/10.1016/j.jaad.2011.02.038.

Guégan S, Lanternier F, Rouzaud C, Dupin N, Lortholary O. Fungal skin and soft tissue infections. Curr Opin Infect Dis. 2016; 29(2):124-130. https://doi.org/10.1097/QCO.0000000000000252.

Lipner SR, Scher RK. Onychomycosis – a small step for quality of care. Curr Med Res Opin. 2016; 32(5):865-867. https://doi.org/10.1185/03007995.2016.1147026.

Jaishi VL, Parajuli R, Dahal P, Maharjan R. Prevalence and risk factors of superficial fungal infection among patients attending a tertiary care hospital in central Nepal. Interdiscip Perspect Infect Dis. 2022; 3088681. https://doi.org/10.1155/2022/3088681.

Bayona JVM, García CS, Palop NT, Cardona CG. Evaluation of a novel chromogenic medium for Candida spp. identification and comparison with CHROMagar™ Candida for the detection of Candida auris in surveillance samples. Diagn Microbiol Infect Dis. 2020; 98(4):115168. https://doi.org/10.1016/j.diagmicrobio.2020.115168.

Singh PD, Verma KR, Sarswat S, Saraswat S. Non-Candida albicans Candida Species: Virulence Factors and Species Identification in India. Curr Med Mycol. 2021; 7(2):8-13. https://doi.org/10.18502/cmm.7.2.7032.

Heckler I, Sabalza M, Bojmehrani A, Venkataraman I, Thompson C. The need for fast and accurate detection of dermatomycosis. Med Mycol. 2023; 61(5):myad037. https://doi.org/10.1093/mmy/myad037.

Mikailov A, Cohen J, Joyce C, Mostaghimi A. Cost-effectiveness of confirmatory testing before treatment of onychomycosis. JAMA Dermatol. 2016; 152(3):276-281. https://doi.org/10.1001/jamadermatol.2015.4190.

Gold JAW, Benedict K, Dulski TM, Lipner SR. Inadequate diagnostic testing and systemic antifungal prescribing for tinea capitis in an observational cohort study of 3.9 million children, United States. J Am Acad Dermatol. 2023; 15:S0190-9622(23)00189-5. https://doi.org/10.1016/j.jaad.2023.02.009.

Bickers DR, Lim HW, Margolis D, Weinstock MA, Goodman C, Faulkner E, Gould C, Gemmen E, Dall T. The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for investigative dermatology. J Am Acad Dermatol. 2006; 55:490-500. https://doi.org/10.1016/j.jaad.2006.05.048.

Schaller M, Friedrich M, Papini M, Pujol RM, Veraldi S. Topical antifungal-corticosteroid combination therapy for the treatment of superficial mycoses: conclusions of an expert panel meeting. Mycoses. 2016; 59(6):365-373. https://doi.org/10.1111/myc.12481.

Madarasingha NP. Evaluation of practice patterns of general practitioners and dermatologists in treating naive and recalcitrant dermatophytosis – an online survey. Sri Lanka J Dermatol. 2020; 21:10-16. https://slcd.lk/assets/img/member-info/journals/volume-21/sljod-v21-p10-16.pdf.

Verma SB, Zouboulis C. Indian irrational skin creams and steroid-modifified dermatophytosis - an unholy nexus and alarming situation. J Eur Acad Dermatol Venereol. 2018; 32:e426-7. https://doi.org/10.1111/jdv.15025.

Becker P, Lecerf P, Claereboudt J, Devleesschauwer B, Packeu A, Hendrickx M. Superficial mycoses in Belgium: Burden, costs and antifungal drugs consumption. Mycoses. 2020; 63(5):500-508. https://doi.org/10.1111/myc.13063.

Downloads

Published

2024-10-31

How to Cite

Magalhães Gomes de Oliveira, A. G., Batista Carneiro de Oliveira, D., & Ferreira de Oliveira, G. (2024). A 10-year survey of dermatomycoses in Uberaba, southeast Brazil. Acta Biologica Brasiliensia, 7(2), 103–117. https://doi.org/10.18554/acbiobras.v7i2.7965

Issue

Section

Artigos