Correlação entre anti-desmogleína e lesões mucocutâneas em pacientes com pênfigo vulgar ou foliáceo
DOI:
https://doi.org/10.18554/refacs.v7i1.2918Palavras-chave:
Pênfigo, Ensaio de Imunoadsorção Enzimática, Dermatopatias Vesiculobolhosas, Doenças AutoimunesResumo
Essa é uma pesquisa não-probabilística e transversal. O objetivo deste estudo foi correlacionar a imunodetecção de anti-desmogleína 1 e 3 no soro de pacientes com pênfigo vulgar (PV) ou pênfigo foliáceo (PF) com a presença de lesões mucocutâneas. Pacientes foram selecionados por uma amostra de conveniência baseada na demanda espontânea nas unidades de Dermatologia e Medicina Oral da Universidade Federal do Pernambuco, Recife, Brasil, de fevereiro a novembro de 2012. Vinte e seis indivíduos (18 mulheres, 69,2% e 8 homens, 30,8%) foram avaliados, 20 diagnosticados com PV (73,1%) e 6 com PF (26,9%). O teste ELISA foi usado para determinar a presença de anti-desmogleína 1 e 3 no soro. A presença de anti-desmogleína 1 foi associada a lesões na pele (p=0,038) e a de anti-desmogleína 3 a lesões mucosais (p = 0,041). Nesse estudo, o ELISA se mostrou altamente sensível ao DSG1 e ao DSG3, de acordo com o fenótipo da doença.
Referências
De D, Khullar G, Handa S, Joshi N, Saikia B, Minz RW. Correlation between salivary and serum anti-desmoglein 1 and 3 antibody titres using ELISA and between anti-desmoglein levels and disease severity in pemphigus vulgaris. Clin Exp Dermatol. 2017; 42(6):648-50.
Feller L. Immunopathogenic oral diseases: an overview focusing on pemphigus vulgaris and mucous membrane pemphigoid. Oral Health Prev Dent. 2017; 15(2):177–82.
Ruocco V, Ruocco E, Lo Schiavo A, Brunetti G, Guerrera LP, Wolf R. Pemphigus: etiology, pathogenesis, and inducing or triggering factors: facts and controversies. Clin Dermatol. 2013; 31(4):374–81.
Santosh ABR, Addam VRR. Oral mucosal lesion in pa/ents with pemphigus and pemphigoid skin diseases: across sec/onal study from southern India. Dentistry 3000. 2017; 5(1):1-7.
Perks AC. A case of concomitant pemphigus foliaceus and oral pemphigus vulgaris. Head Neck Pathol. 2018; 1(1):1-6.
Tamgadge S, Tamgadge A, Bhatt DM, Bhalerao S, Pereira T. Pemphigus vulgaris. Contemp Clin Dent. 2011; 2(2):134-7.
Neumann-Jensen B, Worsaae N, Dabelsteen E, Ullman S. Pemphigus vulgaris and pemphigus foliaceus coexisting with lichen planus. Br J Dermatol. 1980; 102(5):585–90.
Sharma M. Oral pemphigus vulgaris. J Kathmandu Med Coll. 2015; 4(3):100-3.
Patsatsi A, Kyriakou A, Giannakou A, Pavlitous-Tsiontsi A, Lambropoulos A, Dimitrios Sotiriadis D. Clinical significance of anti-desmoglein -1 and -3 circulating autoantibodies in pemphigus patients measured by Area Index and Intensity Score. Acta Derm Venereol. 2014; 94(2):203-6.
Reeves GMB, Lloyd M, Rajlawat BP, Barker GL, Field EA, Kaye SB. Ocular and oral grading of mucous membrane pemphigoid. Graefes Arch Clin Exp Ophthalmol. 2012; 250(4):611-8.
Ni Riordain R, Shirlaw P, Alajbeg I. World Workshop on Oral Medicine VI: patient reported outcome measures and oral mucosal disease: current status and future direction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120(2):161-71.e20.
Di Zenzo G, Carrozzo M, Chan LS. Urban legend series: mucous membrane pemphigoid. Oral Dis. 2014; 20(1):35–54.
Izumi T, Seishima M, Satoh S, Ito A, Kamija H, Kitajima Y. Pemphigus with features of both vulgaris and foliaceus variants associated with antibodies to 160 and 130 kDa antigens. Br J Dermatol. 1998; 139(4):688-92.
Cunha PR, Bystryn JC, Medeiros EPL, Oliveir,a JR. Sensitivity of indirect immunofluorescence and ELISA in detecting intercellular antibodies in endemic pemphigus foliaceus. Int J Dermatol. 2006; 45(8):914-8.
Oiso N, Yamashita C, Yoshioka K, Amagai M, Komai A, Nagata A. IgG/IgA pemphigus with IgG and IgA antidesmoglein 1 antibodies detected by enzyme-linked immunosorbent assay. Br J Dermatol. 2002; 147(5):1012-7.
Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Shimizu A. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus expressed recombinant desmogleins. J Immunol. 1997; 159(4):2010-7.
Mortazavi H, Khatami A, Seyedin Z, Farahani IV, Daneshpazhoohi M. Salivary desmogleína enzyme-linked immunosorbent assay for diagnosis of pemphigus vulgaris: a noninvasive alternative test to serum assessment. Biomed Res. Int. [Internet]. 2015 [citado em 14 out 2017]; ID 698310:1-7. Disponível em: https://www.hindawi.com/journals/bmri/2015/698310/
Sami N, Bhol C, Ahmed AR. Diagnostic features of pemphigus vulgaris in patients with pemphigus foliaceus: detection of both autoantibodies, long-term follow-up and treatment responses. Clin Exp Immunol. 2001; 125(3):492-8.
Shamim T, Varghese VI, Shameena PM, Sudha S. Pemphigus vulgaris in oral cavity: clinical analysis of 71 cases. Med Oral Patol Oral Cir Bucal. 2008; 13(10):E622-6.
Amagai M. Desmoglein as a target in autoimmunity and infection. J Am Acad Dermatol. 2006; 48(2):244-52.
Kouskoukis CE, Ackerman AB. Vacuoles in the upper part of the epidermis as a clue to eventuation of superficial pemphigus and bullous impetigo. Am J Dermatopathol. 1984; 6(2):183-6.
Ito T, Moriuchi R, Kikuchi K, Shimizu S. Rapid transition from pemphigus vulgaris to pemphigus foliaceus. J Eur Acad Dermatol Venereol. 2016; 30(3):455-7.
McMillan R, Taylor J, Shephard M, Ahmed R, Carrozzo M, Setterfield J, et al. World Workshop on Oral Medicine VI: a systematic review of the treatment of mucocutaneous pemphigus vulgaris. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120(2):132-42.
Teixeira TA, Fiori FCBC, Silvestre MC, Borges CB, Maciel VG, Costa MB. Refractory endemic pemphigus foliaceous in adolescence successfully treated with intravenous immunoglobulin. An Bras Dermatol. 2011; 86(4Suppl 1):S133-6.
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