INDIVÍDUOS COM SÍNDROME DE KLINEFELTER PODEM TER FILHOS?
DOI:
https://doi.org/10.18554/dmmmkd61Keywords:
Síndrome de Klinefelter, Infertilidade, CariótipoAbstract
A síndrome de Klinefelter (SK) é a causa genética mais comum de infertilidade masculina. As frequências de infertilidade e azoospermia entre indivíduos com SK são >99% e >95%, respectivamente. No entanto, em casos extremamente raros, pacientes com SK terão filhos. Este estudo tem como objetivo apresentar os resultados de três artigos científicos (3 relatos de caso e 2 artigos originais) sobre indivíduos com SK que tiveram filhos. Nossos resultados indicam que há relativa escassez de dados publicados sobre este tema na literatura, destacando que a parentalidade biológica em indivíduos com SK é extremamente rara.
References
1. Gravholt CH, Chang S, Wallentin M, Fedder J, Moore P, Skakkebæk A. Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology. Endocrine Reviews. 2018; 39(4): 389-423. https://doi.org/10.1210/er.2017-00212.
2. Blackburn J, Ramakrishnan A, Graham C, Bambang K, Sriranglingam U, Senniappan S. Klinefelter Syndrome: A Review. Clinical Endocrinology (Oxf). 2025; 102(5): 565-573. https://doi.org/10.1111/cen.15200.
3. Xu WQ, Yuan Y, Chen Y, Luo T, Chen HY. Birth of a boy after intracytoplasmic sperm injection using ejaculated spermatozoa from a nonmosaic klinefelter syndrome man with normal sperm motility: A case report. Frontiers in Genetics. 2022; 13: 989701. https://doi.org/10.3389/fgene.2022.989701.
4. Elzeiny H, Agresta F, Stevens J, Gardner DK. A rare case of mosaic Klinefelter syndrome in a 45-year-old man leading to successful live birth through ejaculated spermatozoa: a case report and literature review. Frontiers in Genetics. 2023; 14: 1242180. https://doi.org/10.3389/fgene.2023.1242180.
5. Mendonça F, Souto S, Dória S, Carvalho D. Klinefelter syndrome: The characterization of the clinical and sociological features of 51 patients. Revista Internacional de Andrología. 2023; 21(3): 100349. https://doi.org/10.1016/j.androl.2023.100349.
6. Pinheiro MMM, Xavier HR, Garcia Filho R de A, Araujo C de, Medeiros MMWY de. Síndrome de Klinefelter e reprodução assistida: relato de caso clínico e revisão da literatura. Brazilian Journal of Health Review. 2024; 7(4): 1-10. https://doi.org/10.34119/bjhrv7n4-383.
7. Fedder J, Skakkebæk A, Jensen CFS, Gravholt CH. Fertilitetsbehandling af mænd med Klinefelters syndrom [Fertility treatment of men with Klinefelter syndrome]. Ugeskrift for Laeger. 2025; 187(12): V10240694. Danish. https://doi.org/10.61409/V10240694.
8. Chen X, Zhang X, Jiang T, Xu W. Klinefelter syndrome: etiology and clinical considerations in male infertility. Biology of Reproduction 2024; 111(3): 516-528. https://doi.org/10.1093/biolre/ioae076.
9. Bradshaw AW, Deebel NA, Xu MC, Kogan S, Atala A, Sadri-Ardekani H. Examining potential mechanisms of testicular fibrosis in Klinefelter Syndrome: A review of current understanding. Andrology. 2023; 11(3): 435-443. https://doi.org/10.1111/andr.13327.
Downloads
Published
Issue
Section
License
The author(s) retain(s) the rights to the published material. However, publication automatically implies the transfer of copyright, without payment from the journal. The author(s) transfer(s) their economic rights (the right to publish, reproduce, distribute) to the journal. The author(s) do not receive(s) financial remuneration from the Acta Biologica Brasiliensia journal for publishing; the consideration is the dissemination of their work. The author retains authorship (moral rights), but, to publish, transfers or licenses the rights of commercial/economic exploitation (economic rights) to the Acta Biologica Brasiliensia journal, free of charge, making the article open access or, in traditional models, the property of the publisher.
Revistas UFTM