Cardiac weight in elderly men with chronic chagas heart disease

Flávia Aparecida Oliveira; Joana Estela Rezende Vilela; Larissa Oliveira Queiroz; Douglas Montielle Silva Nascimento; Vicente de Paula Antunes Teixeira; Eliza Carla Barroso Duarte; Liliana Borges Menezes; Juliana Reis Machado; Marlene Antônia Reis

doi:10.18554/refacs.v5i3.1994

Authors

Flávia Aparecida Oliveira Department of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia - Goiás, Brazil http://orcid.org/0000-0001-7881-6024
Joana Estela Rezende Vilela Department of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia - Goiás, Brazil http://orcid.org/0000-0003-3449-0354
Larissa Oliveira Queiroz Department of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia - Goiás, Brazil http://orcid.org/0000-0002-9015-3507
Douglas Montielle Silva Nascimento Department of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia - Goiás, Brazil http://orcid.org/0000-0001-5918-0374
Vicente de Paula Antunes Teixeira Discipline of General Pathology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil http://orcid.org/0000-0002-0195-8646
Eliza Carla Barroso Duarte Department of Pathology, School of Medicine, University of Brasília, Brasília, Brazil http://orcid.org/0000-0002-9492-5391
Liliana Borges Menezes Department of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia - Goiás, Brazil http://orcid.org/0000-0003-4237-6279
Juliana Reis Machado Department of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia - Goiás, Brazil http://orcid.org/0000-0002-8673-7788
Marlene Antônia Reis Discipline of General Pathology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil http://orcid.org/0000-0002-8594-7636

DOI:

https://doi.org/10.18554/refacs.v5i3.1994

Keywords:

Aging, Chagas Cardiomyopathy, Fibrosis

Abstract

The aim of this study was to correlate histopathological alterations of chronic Chagas heart disease with cardiac weight in elderly men. Sixteen hearts from patients with chronic Chagas’ heart disease were analyzed. The thickness of the myocardiocytes and their nuclei, the density of the mononuclear infiltrate and the nuclei of myocardiocytes and myocardial fibrosis were quantified in the left myocardium. Cardiac weight was 418.7±136.3g. Also, the cardiac weight presented a positive and significant correlation with the thickness of the cardiomyocytes and their nuclei (rS=0.363 and rS=0.120, respectively p<0.05) and with interstitial fibrosis (rS=0.104 p<0.05). Otherwise, no significant correlation was observed between cardiac weight and mononuclear infiltrate (rS=-0.0118 p>0.05). The density of the cardiomyocyte nuclei presented a negative and significant correlation with cardiac weight (rS= -0.555 p<0.05). Therefore, the increase of cardiac weight in chagasic elderly men was influenced by interstitial fibrosis, myocardial hypertrophy and the destruction of cardiomyocyte.

References

Instituto Brasileiro de Geografia e Estatística (IBGE). http://www.ibge.gov.br/home/estatistica/populacao/projecao_da_populacao/2013/default_tab.shtm

Vasconcelos AMN, Gomes MMF. Transição demográfica: a experiência brasileira. Epidemiol Serv Saúde. 2012; 21(4):539-48.

Santos LNBA, Rocha MS, Oliveira EN, Moura CAG, Araujo AJS, Gusmão IM, et al. Decompensated chagasic heart failure versus non-chagasic heart failure at a tertiary care hospital: Clinical characteristics and outcomes. Rev Assoc Med Bras. 2017; 63(1):57-63.

Lima e Costa MF, Barreto SM, Guerra HL, Firmo JO, Uchoa E, Vidigal PG. Ageing with Trypanosoma cruzi infection in a community where the transmission has been interrupted: the Bambuí Health and Ageing Study (BHAS). Int J Epidemiol. 2001; 30(4):887-93.

Lima-Costa MF, Firmo JO, Uchoa E. Cohort profile: the Bambui (Brazil) Cohort Study of Ageing. Int J Epidemiol. 2011; 40(4):862-7.

Ribeiro AL, Marcolino MS, Prineas RJ, Lima-Costa MF. Electrocardiographic abnormalities in elderly Chagas disease patients: 10-year follow-up of the Bambui Cohort Study of Aging. J Am Heart Assoc. 2014;3(1):1-13.

Lima-Costa MF, Castro-Costa E, Uchôa E, Firmo J, Ribeiro AL, Ferri CP, et al. A population-based study of the association between Trypanosoma cruzi infection and cognitive impairment in old age (the Bambuí Study). Neuroepidemiology 2009; 32(2):122-8.

Higuchi ML, Benvenuti LA, Martins Reis M, Metzger M. Pathophysiology of the heart in Chagas' disease: current status and new developments. Cardiovasc Res. 2003; 60(1):96-107.

Lopes ER, Chapadeiro E, Andrade ZA, Almeida HO, Rocha A. Contribuição ao estudo da anatomia patológica dos corações de chagásicos falecidos subitamente. Revista da Sociedade Brasileira de Medicina Tropical. 1975; 9:262-82.

Bestetti RB, Ramos CP, Godoy RA, Oliveira JS. Chronic Chagas' heart disease in the elderly: a clinicopathologic study. Cardiology. 1987; 74(5):344-51.

Moncayo A, Ortiz Yanine MI. An update on Chagas disease (human American trypanosomiasis). Ann Trop Med Parasitol. 2006; 100(8):663-77.

Gurgel CBFM, Ferreira MCF, Mendes CR, Coutinho E, Favoritto P, Carneiro F. A lesão apical em cardiopatas chagásicos crônicos: estudo necroscópico. Revista da Sociedade Brasileira Medicina Tropical. 2010; 43:709-12.

Hodkinson I, Pomerance A, Hodkinson HM. Heart size in the elderly: a clinicopathological study. J R Soc Med. 1979; 72(1):13-6.

Oliveira FA, Teixeira VP, Lino RS, Vinaud MC, Reis MA. Macroscopic aspects of chronic Chagas heart disease in aging. Arq Bras Cardiol. 2007; 88(4):486-90.

Olivetti G, Massimo M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reative cellular hypertrophy. Circ Res. 1991; 68(6):1560-8.

Villari B, Campbell SE, Schneider J, Vassalli G, Chiariello M, Hess OM. Sex-dependent differences in left ventricular function and structure in chronic pressure overload. Eur Heart J. 1995; 16(10):1410-9.

Willians MA. Quantitative methods in biology. In: Pratical methods in electron microscopy. Editted by Glaubert AM. Elsevier North-Holland Biomedical Press. Amsterdam, The Nederlands, 1977. 233p.

Higuchi ML, Fukasawa S, Brito T, Parzianello LC, Bellotti G, Ramires JA. Different microcirculatory and interstitial matrix patterns in idiopathic dilated cardiomyopathy and Chagas' disease: a three dimensional confocal microscopy study. Heart. 1999; 82(3):279-85.

Rossi MA, Ramos SG. Pathogenesis of chronic Chagas' myocarditis: An overview. Cardiovasc Pathol. 1996; 5(4):197-202.

Satoh F, Tachibana H, Hasegawa I, Osawa M. Sudden death caused by chronic Chagas disease in a non-endemic country: Autopsy report. Pathol Int. 2010; 60(3):235-40.

Tavares-Neto J. Correlação do peso do coração de chagásicos e controles, com algumas características anatomopatológicas. Rev Pat Trop. 1990; 19:25-34.

Chapadeiro E, Lopes ER, Pereira FEL. Denervação parassimpática e hipertrofia do miocárdio em chagásicos crônicos. Rev Inst Med Trop. 1967; 9:40-2.

Teixeira VPA, Magalhães EP, Castro ECC, Guimaraes JV, Pinto ML, Nascimento RB, et al. Peso Cardíaco em Chagásicos Crônicos com ninhos de Trypanosoma cruzi na veia central da supra-renal. Arq Bras Card. 1995; 64(4):315-7.

Tafuri WL, Chapadeiro E. O peso do coração no brasileiro adulto normal. Hospital. 1966; 70:74.

Kitzman DW, Edwards WD. Age-related changes in the anatomy of the normal human heart. J Gerontol. 1990; 45(2):M33-9.

Cardiac weight in elderly men with chronic chagas heart disease

Authors

DOI:

Keywords:

Abstract

References

Downloads

Published

How to Cite

Issue

Section

License

Language

Make a Submission