Prevalence of adverse effects of external beam teletherapy in patients with cervical cancer in the Serra Catarinense region, in Southern Brazil
DOI:
https://doi.org/10.18554/refacs.v11i2.6879Keywords:
Radiotherapy, Teletherapy, Drug-Related side effects and adverse reactions, Toxicity, Uterine cervical neoplasmsAbstract
Objective: to analyze the frequency of adverse effects in patients with cervical cancer undergoing external beam radiation therapy (teletherapy) in a cancer treatment center. Methods: cross-sectional, exploratory and descriptive study, carried out between May and June 2022, through interviews and documentary research, in the Serra Catarinense region, in Southern Brazil. Results: seven patients aged between 38 and 64 years, in different stages of the disease, were considered. The most common adverse effects presented were diarrhea, intestinal pain, abdominal cramps, rectal urgency and dysuria; therefore, the gastrointestinal and urinary systems are the most affected by the treatment. Conclusion: the use of methods that reduce the occurrence of the effects of external beam radiation therapy is an investigative demand, since these effects directly imply the quality of life and well-being of patients.
References
Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health [Internet]. 2022 [citado em 22 jun 2023]. Disponível em: https://www.thelancet.com/action/showPdf?pii=S2214-109X%2822%2900501-0
Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: incidência do câncer no Brasil [Internet]. Rio de Janeiro: INCA; 2019 [citado em 10 jun 2023]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020-incidencia-de-cancer-no-brasil.pdf
Okunade KS. Human papillomavirus and cervical cancer. J Obstet Gynaecol. [Internet]. 2019 [citado em 22 jun 2023]; 40(5):602-8. Disponível em: https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1634030
Wang R, Pan W, Jin L, Huang W, Li Y, Wu D, et al. Human papillomavirus vaccine against cervical cancer: opportunity and challenge. Cancer Lett. [Internet]. 2020 [citado em 22 jun 2023]; 471:88-102. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304383519306044/pdfft?md5=0cd94452917ecd66eb03faa8c245e3f3&pid=1-s2.0-S0304383519306044-main.pdf
Instituto Nacional de Câncer José Alencar Gomes da Silva. Câncer do colo de útero [Internet]. Rio de Janeiro: INCA; 2021[citado em 22 jun 2023]. Disponível em: https://www.gov.br/inca/pt-br/assuntos/cancer/tipos/colo-do-utero
Hill EK. Updates in cervical cancer treatment. Clin Obstet Gynecol. [Internet]. 2020 [citado em 22 jun 2023]; 63(1):3-11. Disponível em: https://journals.lww.com/clinicalobgyn/Abstract/2020/03000/Updates_in_Cervical_Cancer_Treatment.3.aspx
Chargari C, Peignaux K, Escande A, Renard S, Lafond C, Petit A, et al. Radiotherapy of cervical cancer. Cancer Radiothér. [Internet]. 2022 [citado em 22 jun 2023]; 26(1/2):298-308. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1278321821002985?via%3Dihub
Wang K, Tepper JE. Radiation therapy?associated toxicity: etiology, management, and prevention. CA Cancer J Clin. [Internet]. 2021 [citado em 22 jun 2023]; 71(5):437-54. Disponível em: https://acsjournals.onlinelibrary.wiley.com/doi/epdf/10.3322/caac.21689
Pimentel NBL, Modesto FC, Lima VCGS, Andrade KBS, Oliveira AM, Fuly PSC, et al. O câncer do colo uterino e o impacto psicossocial da radioterapia pélvica: revisão integrativa. Res Soc Dev. [Internet]. 2020 [citado em 9 jun 2023]; 9(10):e6489109052. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/9052/8144
Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. The Lancet [Internet]. 2019 [citado em 9 jun 2023]; 393(10167):169-82. Disponível em: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32470-X/fulltext
Ministério da Saúde (Brasil). TabNet. Banco de dados do Sistema Único de Saúde – DATASUS [Internet]. Brasília, DF: Ministério da Saúde; 2022 [citado em 8 jun 2023]. Disponível em: https://datasus.saude.gov.br/informacoes-de-saude-tabnet/
Klopp AH, Yeung AR, Deshmukh S, Gil KM, Wenzel L, Westin SN, et al. Patient-reported toxicity during pelvic intensity-modulated radiation therapy: NRG Oncology–RTOG 1203. J Clin Oncol. [Internet]. 2021 [citado em 22 jun 2023]; 36(24):2538-44. Disponível em: https://ascopubs.org/doi/pdf/10.1200/JCO.2017.77.4273?role=tab
Pacagnella RC, Vieira EM, Rodrigues Junior OM, Souza C. Adaptação transcultural do Female Sexual Function Index. Cad Saúde Pública [Internet]. 2008 [citado em 15 jan 2023]; 24:416-26. Disponível em: https://www.scielo.br/j/csp/a/nY9ccghRJXLB3kHfbvsMhpz/?format=pdf&lang=pt
Isohashi F, Takano T, Onuki M, Arimoto T, Kawamura N, Hara R, et al. A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors. Int J Clin Oncol. [Internet] 2018 [citado em 15 jan 2023]; 24(5):575-82. Disponível em: https://link.springer.com/content/pdf/10.1007/s10147-018-01380-z.pdf?pdf=button
Wild CP, Weiderpass E, Stewart BW, editores. World cancer report: cancer research for cancer prevention. Lyon, France: International Agency for Research on Cancer; 2020 [citado em 12 jul 2022]. Disponível em: https://shop.iarc.fr/products/world-cancer-report-cancer-research-for-cancer-prevention-pdf
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S. Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients. BMC Cancer. [Internet]. 2022 [citado em 15 jan 2023]; 22:371. Disponível em: https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-022-09480-w.pdf
Marks LB, Yorke ED, Jackson A, Ten Haken RK, Constine LS, Eisbruch A, et al. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys. [Internet]. 2010 [citado em 15 jan 2023];76(3 Suppl):S10-S19. Disponível em: https://www.redjournal.org/action/showPdf?pii=S0360-3016%2809%2903288-X
Wit EMK, Horenblas S. Urological complications after treatment of cervical cancer. Nature Reviews Urology [Internet]. 2014 [citado em 15 jan 2023]; 11(2):110-7. Disponível em: https://www.nature.com/articles/nrurol.2013.323
Noronha IDR, Pinto EN, Pires ADS, Pérez Júnior EF, Noronha IDR, Jomar RT. Diagnósticos de enfermagem em pacientes com câncer submetidos à radioterapia: estudo de revisão. Revista RECIEN - Revista Científica de Enfermagem [Internet]. 2021 [citado em 22 jun 2023]; 11(36):153-63. Disponível em: https://recien.com.br/index.php/Recien/article/view/501/520
Soulé T, Sade J, Giornelli G, Orlando M, Rivero S, Chacón M, et al. Análisis retrospectivo institucional de tratamiento quimio-radioterápico definitivo en cáncer de cuello uterino localmente avanzado. Oncol Clín. [Internet]. 2016 [citado em 22 jun 2023]; 21(3):65-70. Disponível em: http://fi-admin.bvsalud.org/document/view/nrjcv
Fiorino C, Valdagni R, Rancati T, Sanguineti G. Dose–volume effects for normal tissues in external radiotherapy: pelvis. Radiother Oncol. [Internet]. 2009 [citado em 22 jun 2023]; 93(2):153-67. Disponível em: https://www.thegreenjournal.com/article/S0167-8140(09)00437-X/fulltext
Lima LC, Silva TS, Negreiros ASV, Vieira ACQ, Lima SC, Uchôa SMM, et al. Disfunções do assoalho pélvico pós radioterapia para tratamento do carcinoma de colo uterino: uma revisão integrativa. Res Soc Dev. [Internet]. 2021 [citado em 22 jun 2023]; 10(14):e356101422036. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22036/19663
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 JOURNAL FAMILY, CYCLES OF LIFE AND HEALTH IN SOCIAL CONTEXT
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Each of the authors of the manuscript must complete and sign a copy of Statement of Responsibility and Copyright Transfer Agreement, which must be attached, by the submitting author, in step 4 of the submission process in the journal system (Click on the "Browse" option, select the file that should be inserted in pdf format, click on the "Download" button, in the "Title" field type: Declaration of responsibilities, then click the "Save and Continue" button and proceed with the submission process.
Note: Including scanned signature will not be accepted. Each author of the manuscript must complete a declaration individually.
REFACS de Universidade Federal do Triângulo Mineiro está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional.
Baseado no trabalho disponível em www.uftm.edu.br.
Podem estar disponíveis autorizações adicionais às concedidas no âmbito desta licença em http://www.uftm.edu.br/refacs.