Macroprolactinomas in Adolescents and Young Adults

Abstract

Objectives: To evaluate the degree of response to treatment based on the reduction in tumor size, normalization of prolactin levels, restoration of pituitary function and evolution of the neuro-ophthalmological condition. Methods: The work was conducted by reviewing the medical records of six adolescent and young adult patients treated at the Neuroendocrinology outpatient clinic from March 1991 to March 2023, at the Hospital de Clínicas of the Federal University of Triângulo Mineiro. The diagnosed cases of macroprolactinoma and giant prolactinoma were confirmed by laboratory and imaging tests. Results: Among the cases, three were male and three were female. In women, complaints of amenorrhea and headache predominated and in boys, neuro-ophthalmological complaints predominated. Conclusion: Early diagnosis of prolactinomas in adolescents and young adults is a challenge. Addressing macroprolactinomas in this age group represents a fundamental piece in understanding and effectively managing this complex endocrine condition. In-depth discussion of these giant prolactinomas is crucial to inform more effective clinical practices and direct personalized therapeutic interventions.