FARMACOGENÉTICA DA TUBERCULOSE
DOI:
https://doi.org/10.18554/acbiobras.v7i1.7654Keywords:
Tuberculosis, Pharmacogenetic, Anti-TB drugsAbstract
Tuberculosis is a major cause of death worldwide and is especially prevalent in developing countries. It is known that the response to pharmacologic treatments can be influenced by several factors, including genetics, the focus of pharmacogenetics, and ethnicity. We conducted a review of the literature encompassing genes of pharmacogenetic interest to evaluate the data currently available in reference to treatment response alterations, allele frequencies, and interethnic differences. Through our statistical analyses, we were able to point out potential protective and risk variants for several ethnicities, especially for NAT2 gene, indicating future paths to be pursued by further initiatives for a future of safer and more effective tuberculosis treatments.
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