AS CÉLULAS DENDRÍTICAS COMO FERRAMENTA DE IMUNOTERAPIA

Abstract

Dendritic cells (DCs) are antigen-presenting cells that orchestrate the innate and adaptive immune response. These cells in their mature state have the characteristic of binding to T lymphocyte receptors through the specificities present in DC histocompatibility molecules that are attracted to T receptors (TCR). The interaction between DCs and T lymphocytes guarantees the immunological synapse, which results in clonal expansion of T lymphocytes, production of cytokines and chemokines, a diagram that configures the effectiveness of immunological responses in the face of recognized homeostasis disorders. Recently, the role of DCs in pathologies associated with the immune system was discovered, as it is associated with the induction or suppression of autoreactive T cell responses. The capacity of immunotherapies with DCs for therapeutic interventions in cancers, HIV, autoimmune diseases and adaptations improved physiological characteristics in transplants contributes to a new perspective on the disparate functionalities of these cells. The study of the applications of DCs in the management of clinical conditions is totally relevant not only for their application as monotherapies, but also for their association with other therapeutic alternatives with the prospect of finding promising treatments and cures. In this sense, it is important to understand the applicability of DCs in therapeutic interventions in different scenarios, in order to improve existing treatments and also discover new approaches related to these cells, a set that guarantees positive results in public health.