POLYMORPHISMS IN THE VEGF GENE TO THE DEVELOPMENT OF GESTATIONAL HYPERTENSIVE SYNDROMES: A LITERATURE REVIEW

Authors

  • Sarah Cristina Sato Vaz Tanaka UFTM
  • Cristina Wide Pissetti UFTM
  • Sueli Riul Silva UFTM
  • Marly Aparecida Spadotto Balarin UFTM

DOI:

https://doi.org/10.18554/

Abstract

Studies of susceptibility genes for Gestational Hypertensive Syndromes (SGH) are based on the most accepted hypotheses about its etiopathogenesis, such as placental ischemia and endothelial dysfunction. During pregnancy, the Factor Vascular Endothelial Growth (VEGF) regulates angiogenesis and acts in spiral artery remodeling. This literature review examined the association of genetic polymorphisms in the VEGF gene with the SHG in the period 2004-2013, using Pubmed as a research resource. Polymorphisms +405 G/C and-2578 C/A were associated with reduced risk of developing preeclampsia (PE), +936 C/T confers increased risk for the development and severity of PE. The polymorphisms rs7664413, rs1485766 and rs6838834 are associated with the risk of developing PE only in white women and black women, respectively. Thus, some contradictory results were due to the fact that studies involving genetic polymorphisms are complex and may be valid in a population but not in another. Key Words: Polymorphism, Genetic, Hypertension, Pregnancy-Induced, Vascular Endothelial Growth Factor A

Author Biographies

Sarah Cristina Sato Vaz Tanaka, UFTM

Mestranda do Programa de Pós Graduação em Ciências da Saúde; UFTM (Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil).

Cristina Wide Pissetti, UFTM

PhD, pós-doc, Instituto de Ciências da Saúde; Programa de Pós Graduação em Atenção a Saúde; Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil.

Sueli Riul Silva, UFTM

Enfermeira. Doutora em Enfermagem Fundamental. Professora Associada do Centro de Graduação em Enfermagem da UFTM.

Marly Aparecida Spadotto Balarin, UFTM

Bióloga. Doutora em Genética. Disciplina de Genética; Instituto de Ciências Biológicas e Naturais, UFTM.

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Issue

Vol. 3 No. 2 (2014)

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Revisão

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