POLIMORFISMOS EN EL GEN VEGF PARA EL DESARROLLO DE LOS SÍNDROMES HIPERTENSIVOS DE LA GESTACIÓN: UNA REVISIÓN DE LA LITERATURA

Autores/as

  • Sarah Cristina Sato Vaz Tanaka UFTM
  • Cristina Wide Pissetti UFTM
  • Sueli Riul Silva UFTM
  • Marly Aparecida Spadotto Balarin UFTM

DOI:

https://doi.org/10.18554/

Resumen

Estudios de genes de susceptibilidad para Síndromes Hipertensivas Gestacionales (SGH) son basados en las hipótesis más aceptas sobre su etiopatogenia, como la isquemia placentaria y la disfunción endotelial. En la gestación, el Factor de Crecimiento del Endotelio Vascular (VEGF) regula la angiogenese y actúa en el remodelamiento de la arteria espiralada. Esta revisión bibliográfica evaluó la asociación de polimorfismos genéticos en el gene VEGF con las SHG, en el período de 2004 hasta 2013, utilizando el Pubmed como fuente de pesquisa. Los polimorfismos +405G/C e -2578C/A fueron asociados a la reducción del riesgo de desarrollar pre-eclámpsia (PE), +936C/T confiere riesgo mayor para desenvolvimiento y gravedad de PE. Los polimorfismos rs7664413, rs1485766 y rs6838834 están asociados al riesgo de desenvolvimiento de PE apenas en mujeres blancas y mujeres negras, respectivamente. Así, algunos resultados se muestrearon contradictorios, debido al facto de que estudios envolviendo polimorfismos genéticos son complejos y pueden ser válidos en una población, pero no en otra. Palabras Clave: Polimorfismo genético, Factor de Crecimiento Endotelial Vascular (VEGF), hipertensión inducida por el embarazo.

Biografía del autor/a

Sarah Cristina Sato Vaz Tanaka, UFTM

Mestranda do Programa de Pós Graduação em Ciências da Saúde; UFTM (Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil).

Cristina Wide Pissetti, UFTM

PhD, pós-doc, Instituto de Ciências da Saúde; Programa de Pós Graduação em Atenção a Saúde; Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil.

Sueli Riul Silva, UFTM

Enfermeira. Doutora em Enfermagem Fundamental. Professora Associada do Centro de Graduação em Enfermagem da UFTM.

Marly Aparecida Spadotto Balarin, UFTM

Bióloga. Doutora em Genética. Disciplina de Genética; Instituto de Ciências Biológicas e Naturais, UFTM.

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Número

Vol. 3 Núm. 2 (2014)

Sección

Revisão

Licencia

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